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  1. Home/
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  3. MLB/
  4. Seattle Mariners vs Houston Astros

Seattle Mariners vs Houston AstrosMLB Picks, Prediction & Odds • Sep 23 • 10:11 PM

Seattle Mariners logo

Seattle Mariners

0-0
Starting Now
Houston Astros logo

Houston Astros

12Picks

Experts Betting This Game

12 experts have a pick on Seattle Mariners vs Houston Astros

View Expert Picks
Knup Sports - POTD

Knup Sports - POTD

70% Win Rate
Pick on this game
Premium pick +100Unlock
Tyler Williams

Tyler Williams

70% Win Rate
Pick on this game
Premium pick +100Unlock
Pro Picks - Ben

Pro Picks - Ben

70% Win Rate
Pick on this game
Premium pick +100Unlock
Logan Wilson

Logan Wilson

70% Win Rate
Pick on this game
Premium pick +100Unlock
Al Grant

Al Grant

70% Win Rate
Pick on this game
Premium pick +100Unlock
Knup Sports - POTD

Knup Sports - POTD

70% Win Rate
Pick on this game
Premium pick +100Unlock
Tyler Williams

Tyler Williams

70% Win Rate
Pick on this game
Premium pick +100Unlock
Pro Picks - Ben

Pro Picks - Ben

70% Win Rate
Pick on this game
Premium pick +100Unlock
Logan Wilson

Logan Wilson

70% Win Rate
Pick on this game
Premium pick +100Unlock
Al Grant

Al Grant

70% Win Rate
Pick on this game
Premium pick +100Unlock

Our Prediction

Seattle Mariners logoSeattle Mariners55%
45%Houston AstrosHouston Astros logo
Seattle Mariners logo
Seattle Mariners
VS
Houston Astros logo
Houston Astros
Confidence
Low

We predict Seattle Mariners

Key Factors

Betting Odds

Betting odds imply a 55% chance for Seattle Mariners

12

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Seattle Mariners logoSeattle Mariners
Houston AstrosHouston Astros logo
Spread
-1.50
+155
1.50
-189
Moneyline
-133
FAV
+112
Total (O/U 7.50)
Over
-114
Under
-108

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Frequently asked questions

Who is favored to win Seattle Mariners vs Houston Astros?▾

Seattle Mariners are favored over Houston Astros based on the latest moneyline (Seattle Mariners -133, Houston Astros +112).

What is the point spread for Seattle Mariners vs Houston Astros?▾

Seattle Mariners -1.50, Houston Astros 1.50. Spread reflects the projected margin between the two teams.

What is the over/under for Seattle Mariners vs Houston Astros?▾

The total (over/under) is 7.50. Over 7.50 or under 7.50 wins respectively.

When is Seattle Mariners vs Houston Astros?▾

Seattle Mariners vs Houston Astros is scheduled for Sep 23 at 10:11 PM ET.

More MLB picks

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    Wed, Sep 23
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    Wed, Sep 23
  • New York Yankees vs Tampa Bay Rays
    Wed, Sep 23
  • Boston Red Sox vs Cleveland Guardians
    Wed, Sep 23
  • Atlanta Braves vs Cincinnati Reds
    Wed, Sep 23
  • Chicago Cubs vs Miami Marlins
    Wed, Sep 23
See all MLB picks →
12

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Seattle Mariners logoSeattle Mariners
Houston AstrosHouston Astros logo
Spread
-1.50
+155
1.50
-189
Moneyline
-133
FAV
+112
Total (O/U 7.50)
Over
-114
Under
-108
GameAdvisers logo

Expert sports betting picks and predictions

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© 2026 GameAdvisers. All rights reserved.

21+Bet responsibly. Picks are for entertainment — gambling involves risk.

GameAdvisers may earn a commission from sportsbook partners linked from this site. Picks and editorial content are produced independently of any partnership. Affiliate Disclosure

Please gamble responsibly. If you have a gambling problem, please visit ncpgambling.org