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  1. Home/
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  3. MLB/
  4. Boston Red Sox vs Cleveland Guardians

Boston Red Sox vs Cleveland GuardiansMLB Picks, Prediction & Odds • Sep 23 • 07:11 PM

Boston Red Sox logo

Boston Red Sox

0-0
Starting Now
Cleveland Guardians logo

Cleveland Guardians

12Picks

Experts Betting This Game

12 experts have a pick on Boston Red Sox vs Cleveland Guardians

View Expert Picks
Knup Sports - POTD

Knup Sports - POTD

70% Win Rate
Pick on this game
Premium pick +100Unlock
Sports Hub - FREE PICKS

Sports Hub - FREE PICKS

70% Win Rate
Pick on this game
Premium pick +100Unlock
Randall Dickelman

Randall Dickelman

70% Win Rate
Pick on this game
Premium pick +100Unlock
Sports Central

Sports Central

70% Win Rate
Pick on this game
Premium pick +100Unlock
Sas Insider

Sas Insider

70% Win Rate
Pick on this game
Premium pick +100Unlock
Knup Sports - POTD

Knup Sports - POTD

70% Win Rate
Pick on this game
Premium pick +100Unlock
Sports Hub - FREE PICKS

Sports Hub - FREE PICKS

70% Win Rate
Pick on this game
Premium pick +100Unlock
Randall Dickelman

Randall Dickelman

70% Win Rate
Pick on this game
Premium pick +100Unlock
Sports Central

Sports Central

70% Win Rate
Pick on this game
Premium pick +100Unlock
Sas Insider

Sas Insider

70% Win Rate
Pick on this game
Premium pick +100Unlock

Our Prediction

Boston Red Sox logoBoston Red Sox55%
45%Cleveland GuardiansCleveland Guardians logo
Boston Red Sox logo
Boston Red Sox
VS
Cleveland Guardians logo
Cleveland Guardians
Confidence
Low

We predict Boston Red Sox

Key Factors

Betting Odds

Betting odds imply a 55% chance for Boston Red Sox

12

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Boston Red Sox logoBoston Red Sox
Cleveland GuardiansCleveland Guardians logo
Spread
-1.50
+167
1.50
-204
Moneyline
-137
FAV
+113
Total (O/U 6.50)
Over
-119
Under
-101

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Frequently asked questions

Who is favored to win Boston Red Sox vs Cleveland Guardians?▾

Boston Red Sox are favored over Cleveland Guardians based on the latest moneyline (Boston Red Sox -137, Cleveland Guardians +113).

What is the point spread for Boston Red Sox vs Cleveland Guardians?▾

Boston Red Sox -1.50, Cleveland Guardians 1.50. Spread reflects the projected margin between the two teams.

What is the over/under for Boston Red Sox vs Cleveland Guardians?▾

The total (over/under) is 6.50. Over 6.50 or under 6.50 wins respectively.

When is Boston Red Sox vs Cleveland Guardians?▾

Boston Red Sox vs Cleveland Guardians is scheduled for Sep 23 at 07:11 PM ET.

More MLB picks

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    Wed, Sep 23
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    Wed, Sep 23
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    Wed, Sep 23
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    Wed, Sep 23
  • Philadelphia Phillies vs Milwaukee Brewers
    Wed, Sep 23
  • New York Yankees vs Tampa Bay Rays
    Wed, Sep 23
See all MLB picks →
12

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Boston Red Sox logoBoston Red Sox
Cleveland GuardiansCleveland Guardians logo
Spread
-1.50
+167
1.50
-204
Moneyline
-137
FAV
+113
Total (O/U 6.50)
Over
-119
Under
-101
GameAdvisers logo

Expert sports betting picks and predictions

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© 2026 GameAdvisers. All rights reserved.

21+Bet responsibly. Picks are for entertainment — gambling involves risk.

GameAdvisers may earn a commission from sportsbook partners linked from this site. Picks and editorial content are produced independently of any partnership. Affiliate Disclosure

Please gamble responsibly. If you have a gambling problem, please visit ncpgambling.org