By the time the second top-10 game of the day kicked off at Death Valley, Arch Manning’s Heisman Trophy odds were on life support.

A pick, one touchdown and subpar numbers in general sent Manning’s odds to win the 2025 Heisman south rapidly.

The quarterbacks involved in the Saturday evening game in South Carolina, Clemson’s Cade Klubnik and LSU’s Garrett Nussmeier, were moved to co-favorites before either took a snap.

Their 15-2 odds (+700) on FanDuel were far superior to Manning’s, who went from 5-1 odds at kickoff of the noon ET game at Ohio State to +1800. Buckeyes wide receiver Jeremiah Smith, Georgia quarterback Gunner Stockton, South Carolina quarterback La’Norris Sellers and Oklahoma quarterback John Mateer all jumped to +1600 on Saturday.

Manning finished with pedestrian passing numbers in the No. 1 Longhorns’ 14-7 loss to the No. 3 Buckeyes. He completed 17 of 30 for 170 yards, one touchdown and an interception in the third quarter on a throw he would love to have back.

Penn State quarterback Drew Allar, Oregon quarterback Dante Moore and Miami quarterback Carson Beck were all +1800, even with Manning. The Hurricanes play Notre Dame on Sunday night.

Updated Heisman Trophy odds from FanDuel (Saturday, 7:45 p.m. ET): Cade Klubnik (Clemson), +700 Garrett Nussmeier (LSU), +700 John Mateer (Oklahoma), +1600 LaNorris Sellers (South Carolina), +1600 Jeremiah Smith (Ohio State), +1600 Gunner Stockton (Georgia), +1600 Carson Beck (Miami), +1800 Dante Moore (Oregon), +1800 Drew Allar (Penn State), +1800 Arch Manning (Texas), +1800 Jackson Arnold (Auburn), +2000 Sam Leavitt (Arizona State), +2000 Julian Sayin (Ohio State), +2500 DJ Lagway (Florida), +2500 Jeremiyah Love (Notre Dame), +2500 Thomas Castellanos (Florida State), +3300 Marcel Reed (Texas A&M), +3500 Kevin Jennings (SMU), +3500 Austin Simmons (Ole Miss), +3500