NFL Picks Week 6 and Betting Lines Movement

There has been some wild betting lines movement already, which will influence the best NFL picks week 6. 

Injuries and COVID-19 are impacting multiple teams. We’re still just finishing up NFL week 5 action, as the Titans host the Bills tonight and our AI picks system has made a prediction for this game. 

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NFL Week 6 Betting Trends

For the first time this season, unders outperformed overs in the NFL. Well, so far anyways. The O/U record is 6-7 through the first 13 games, but there’s still one game left tonight at 7:00 PM ET. 

It was a good week to bet on underdogs as well. Favorites are only 6-7 ATS in NFL week 5 action. 

Four underdogs won straight-up and cashed on the moneyline. The Raiders and Dolphins were both underdogs of more than a TD, but won on the road, paying out huge prices on the ML. 

US sports betting sites have been increasing totals for a couple weeks now and we’re starting to see overs hit less often already. Seven games have a total of 50+ points for NFL picks week 6. 

Analyzing the Opening Lines and Best NFL Picks Week 6

Like every week this season, our resident odds expert analyzes NFL week 6 line movement. We take a look at the point spreads and game totals to identify where the value is. 

We also identify some of our experts’ NFL picks week 6 throughout the preview. 

The Seahawks, Saints, Raiders and Chargers are on a bye week. 

Browns vs. Patriots Week 6 Odds and Pick

Opening Line: Patriots –9.5 / Current Line: Patriots –8.5 

Opening Total: 45.5 Points / Current Total: 45.5 Points 

The Patriots (2-2 / 2-2 ATS) were supposed to play the Broncos (1-3 / 3-1 ATS) in week 5, but NE has had a COVID-19 outbreak. With Newton out, Stidham is expected to start for the Patriots. 

Texans vs. Titans Week 6 Odds and Pick

Opening Line: Titans –5.5 / Current Line: OTB 

Opening Total: OTB / Current Total: OTB 

We’ll have to wait to see where this line reopens after tonight’s Titans (3-0 / 0-3) game. The Texans (1-4 / 1-4 ATS) won their first game in W5. If HOU is an underdog, we like them on the ML. 

Browns vs. Steelers Week 6 Odds and Pick

Opening Line: Steelers –5.5 / Current Line: Steelers –3.5 

Opening Total: 51 Points / Current Total: 51 Points 

The Browns (4-1 / 3-2 ATS) have won four games in a row! The Steelers (4-0 / 3-1 ATS) are undefeated. The home team is 4-0 ATS in the last four H2H meetings, but we like the points in this match-up. 

Ravens vs. Eagles Week 6 Odds and Pick

Opening Line: Ravens –7 / Current Line: Ravens –7.5 

Opening Total: 49 Points / Current Line: 46.5 Points 

The Ravens (4-1 / 3-2 ATS) should have little trouble defeating the Eagles (1-3-1 / 1-4 ATS). The hook might scare some bettors away, but the Ravens will cover against the spread. 

Washington vs. Giants Week 6 Odds and Pick

Opening Line: Giants –3.5 / Current Line: Giants –3 

Opening Total: 44.5 Points / Current Total: 43 Points 

Washington (1-4 / 2-3 ATS) are terrible. Alex Smith got back on the field on the last week, but he’ll never be the same. The Giants (0-5 / 3-2 ATS) are winless, but that’ll change in week 6. 

Falcons vs. Vikings Week 6 Odds and Pick

Opening Line: Vikings –3.5 / Current Line: Vikings –3.5 

Opening Total: 57 Points / Current Total: 54.5 Points 

Both the Falcons (0-5 / 1-4 ATS) and Vikings (1-4 / 3-2 ATS) are struggling mightily. After firing Quinn and Dimitroff, I expect the Falcons to bounce back and pick up their first victory. 

Lions vs. Jaguars Week 6 Odds and Pick

Opening Line: Lions –2.5 / Current Line: Lions –3.5 

Opening Total: 52.5 Points / Current Total: 54.5 Points 

The Lions (1-3 / 1-3 ATS) and Jaguars (1-4 / 2-3 ATS) are two more struggling teams. Detroit are 1-6 ATS in their last 7 on the road and 0-4 ATS in their last 4 as a favorite. Take the points here. 

Bengals vs. Colts Week 6 Odds and Pick

Opening Line: Colts –9.5 / Current Line: Colts –7.5 

Opening Total: 46.5 Points / Current Line: 46.5 Points 

The Colts (3-2 / 3-2 ATS) just lost to the Browns by double-digits, but don’t let that fool you here, they will cover ATS. The Bengals (1-3-1 / 3-2 ATS) defense won’t be able to keep them in this game. 

Bears vs. Panthers Week 6 Odds and Pick

Opening Line: Panthers –3 / Current Line: Panthers –3.5 

Opening Total: 44 Points / Current Total: 44.5 Points 

The Bears (4-1 / 3-2 ATS) are having a great season. Nick Foles might be this year’s Tannehill. Carolina (3-2 / 3-2 ATS) have won three games in a row. The best bet here is on the under. 

Jets vs. Dolphins Week 6 Odds and Pick

Opening Line: Dolphins –8 / Current Line: Dolphins –8 

Opening Total: 49.5 Points / Current Total: 48 Points 

The Dolphins (2-3 / 3-2 ATS) host the winless Jets (0-5 / 0-5 ATS). Only the Cowboys have been as bad ATS as the Jets. This is a big spread for MIA to cover. We’re sitting this game out. 

Packers vs. Buccaneers Week 6 Odds and Pick

Opening Line: Buccaneers –3 / Current Line: Packers –1.5 

Opening Total: 52 Points / Current Total: 54 Points 

The Packers (4-0 / 4-0 ATS) have been perfect this season. The Buccaneers (3-2 / 2-3 ATS) are getting healthier and could have Godwin back. With GB being on the road, this is a tough to predict. 

Rams vs. 49ers Week 6 Odds and Pick

Opening Line: 49ers –3 / Current Line: Rams –3.5 

Opening Total: 49.5 Points / Current Total: 50.5 Points 

The 49ers (2-3 / 2-3) are struggling and have lost two games in a row. The Rams (4-1 / 3-2 ATS) are playing great. The road team is 4-1 ATS in the last 5 H2H meetings. Take the Rams to cover ATS. 

Chiefs vs. Bills Week 6 Odds and Pick

Opening Line: Chiefs –3 / Current Line: Chiefs –3 

Opening Total: 55 Points / Current Total: 55 Points 

Most books have this game OTB until the Bills (4-0 / 3-1 ATS) play tonight. The Chiefs (4-1 / 3-2 ATS) are on the road in this game and we’re taking the points with the Bills at +3. 

Cardinals vs. Cowboys Week 6 Odds and Pick

Opening Line: Cowboys –3 / Current Line: Cardinals –2.5 

Opening Total: 52 Points / Current Total: 54.5 Points 

The Cardinals (3-2 / 3-2 ATS) and Cowboys (2-3 / 0-5 ATS) will likely be the highest-scoring game of the week. We feel the total is a little here and we’ll be all over the over at 54.5 points.