Seattle Seahawks vs San Francisco 49ersNFL Picks, Prediction & Odds • Oct 11 • 12:25 PM

Seahawks

0-0

Starting Now

49ers

8Picks

Experts Betting This Game

8 experts have a pick on Seahawks vs 49ers

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Sports Hub Insider

70% Win Rate

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Sports Hub - FREE PICKS

70% Win Rate

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SWJ Sports

SWJ Sports

30% Win Rate

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Jay Cooper

Jay Cooper

30% Win Rate

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Jesse Schule

Jesse Schule

70% Win Rate

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Sports Hub Insider

70% Win Rate

Pick on this game

Sports Hub - FREE PICKS

70% Win Rate

Pick on this game

SWJ Sports

SWJ Sports

30% Win Rate

Pick on this game

Jay Cooper

Jay Cooper

30% Win Rate

Pick on this game

Jesse Schule

Jesse Schule

70% Win Rate

Pick on this game

Our Prediction

Seahawks44%

56%49ers

Seahawks

3-1National Football Conference #11

VS

49ers

4-0National Football Conference #3

Confidence

Low

We predict San Francisco 49ers

Key Factors

Betting Odds

Betting odds imply a 61% chance for Seahawks

Season Record

49ers is 4-0 this season

Standings Position

49ers ranked #3 in standings

Head-to-Head

Seahawks leads the recent series 2-1

Team Comparison

Seahawks

49ers

Offense

26.3

PPG

30.5

Defense

18.3

Opp PPG

16.0

General

3-1

Record

4-0

75.0%

Win %

100.0%

#11

Ranking

#3

Head-to-Head

Last 3 meetings

2

Seahawks

1

49ers

67%

33%

Recent Matchups

Jan 17, 2026

41-6

Seahawks

Jan 3, 2026

13-3

Seahawks

Sep 7, 2025

13-17

49ers

H2H Averages (Last 3 Games)

22.3

8.7

Seahawks AvgAvg Score49ers Avg

8

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Seahawks

49ers

Spread

-3.00

-115

3.00

+104

Moneyline

-169

FAV

+149

Total (O/U 46.00)

Over

-110

Under

-104

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Frequently asked questions

Who is favored to win Seattle Seahawks vs San Francisco 49ers?

Seattle Seahawks are favored over San Francisco 49ers based on the latest moneyline (Seahawks -169, 49ers +149).

What is the point spread for Seattle Seahawks vs San Francisco 49ers?

Seahawks -3.00, 49ers 3.00. Spread reflects the projected margin between the two teams.

What is the over/under for Seattle Seahawks vs San Francisco 49ers?

The total (over/under) is 46.00. Over 46.00 or under 46.00 wins respectively.

When is Seattle Seahawks vs San Francisco 49ers?

Seattle Seahawks vs San Francisco 49ers is scheduled for Oct 11 at 12:25 PM ET.

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