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  1. Home/
  2. Picks/
  3. NFL/
  4. San Francisco 49ers vs Denver Broncos

San Francisco 49ers vs Denver BroncosNFL Picks, Prediction & Odds • Oct 4 • 04:25 PM

San Francisco 49ers logo

San Francisco 49ers

0-0
Starting Now
Denver Broncos logo

Denver Broncos

6Picks

Experts Betting This Game

6 experts have a pick on San Francisco 49ers vs Denver Broncos

View Expert Picks
Sports Hub Insider

Sports Hub Insider

30% Win Rate
Pick on this game
Premium pick +100Unlock
Sports Hub - FREE PICKS

Sports Hub - FREE PICKS

70% Win Rate
Pick on this game
Premium pick +100Unlock
SWJ Sports

SWJ Sports

30% Win Rate
Pick on this game
Premium pick +100Unlock
Jay Cooper

Jay Cooper

70% Win Rate
Pick on this game
Premium pick +100Unlock
Bobby Babowski

Bobby Babowski

70% Win Rate
Pick on this game
Premium pick +100Unlock
Sports Hub Insider

Sports Hub Insider

30% Win Rate
Pick on this game
Premium pick +100Unlock
Sports Hub - FREE PICKS

Sports Hub - FREE PICKS

70% Win Rate
Pick on this game
Premium pick +100Unlock
SWJ Sports

SWJ Sports

30% Win Rate
Pick on this game
Premium pick +100Unlock
Jay Cooper

Jay Cooper

70% Win Rate
Pick on this game
Premium pick +100Unlock
Bobby Babowski

Bobby Babowski

70% Win Rate
Pick on this game
Premium pick +100Unlock

Our Prediction

San Francisco 49ers logoSan Francisco 49ers57%
43%Denver BroncosDenver Broncos logo
San Francisco 49ers logo
San Francisco 49ers
VS
Denver Broncos logo
Denver Broncos
Confidence
Low

We predict San Francisco 49ers

Key Factors

Betting Odds

Betting odds imply a 57% chance for San Francisco 49ers

6

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

San Francisco 49ers logoSan Francisco 49ers
Denver BroncosDenver Broncos logo
Spread
-2.50
-118
2.50
-102
Moneyline
-145
FAV
+120
Total (O/U 48.00)
Over
-108
Under
-110

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Frequently asked questions

Who is favored to win San Francisco 49ers vs Denver Broncos?▾

San Francisco 49ers are favored over Denver Broncos based on the latest moneyline (San Francisco 49ers -145, Denver Broncos +120).

What is the point spread for San Francisco 49ers vs Denver Broncos?▾

San Francisco 49ers -2.50, Denver Broncos 2.50. Spread reflects the projected margin between the two teams.

What is the over/under for San Francisco 49ers vs Denver Broncos?▾

The total (over/under) is 48.00. Over 48.00 or under 48.00 wins respectively.

When is San Francisco 49ers vs Denver Broncos?▾

San Francisco 49ers vs Denver Broncos is scheduled for Oct 4 at 04:25 PM ET.

More NFL picks

  • Houston Texans vs Dallas Cowboys
    Sun, Oct 4
  • New York Giants vs Arizona Cardinals
    Sun, Oct 4
  • Cleveland Browns vs Pittsburgh Steelers
    Thu, Oct 1
See all NFL picks →
6

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

San Francisco 49ers logoSan Francisco 49ers
Denver BroncosDenver Broncos logo
Spread
-2.50
-118
2.50
-102
Moneyline
-145
FAV
+120
Total (O/U 48.00)
Over
-108
Under
-110
GameAdvisers logo

Expert sports betting picks and predictions

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21+Bet responsibly. Picks are for entertainment — gambling involves risk.

GameAdvisers may earn a commission from sportsbook partners linked from this site. Picks and editorial content are produced independently of any partnership. Affiliate Disclosure

Please gamble responsibly. If you have a gambling problem, please visit ncpgambling.org